Dapagliflozine is an antidiabetic indicated for the treatment of type 2 diabetes mellitus, as it increases glucose through urine, which helps control blood sugar levels. In addition, it is also indicated for the prevention of heart failure or kidney disease in people with type 2 diabetes.
This medicine is provided free of charge by SUS, provided it has medical indication, or purchased in pharmacies or drugstores in the form of 10 mg tablets, such as generic or with the trade names forxiga or edistrid.
Also read: Forxiga: What is it for, how to take (and active ingredient)
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In addition, dapagliflozin can also be found in association with metformin or saxagliptin, with xigu or qtern names, and should be used with indication of the endocrinologist.
So that Serve
Dapagliflozine is indicated for:
- Treatment of type 2 diabetes mellitus, when only diet and exercise were not enough to control blood sugar levels;
- Prevent or prevent heart failure, cardiovascular death or kidney disease in people with type 2 diabetes mellitus;
- Treatment of heart failure;
- Treatment of chronic kidney disease.
Dapagliflozine can be used alone or in association with metformin, insulin or saxagliptin, in order to enhance the effect on the control of type 2 diabetes mellitus.
This medicine should be used with an indication of the endocrinologist and regular medical follow -up, to perform blood glucose exams, have effective control of type 2 diabetes, evaluate the effectiveness of treatment and the emergence of side effects.
How does Dapagliflozina work?
Dapagliflozine works by increasing the elimination of blood glucose through urine.
This is because this remedy inhibits the sodium-glcose 2 (SGLT2) Cotransporter in the kidneys, and thus prevents reabsorption of renal glucose to the bloodstream, and thus helps in control of type 2 diabetes mellitus.
In addition, Dapagliflozine also helps you reduce heart effort to pump blood, and therefore helps prevent or treat heart failure.
How to take
Dapagliflozine should be taken orally with a glass of water before or after a meal.
Dapagliflozine dosage varies according to the compressed composition and includes:
1. Dapagliflozina 10 mg
The Dapagliflozine coated tablet should be taken orally, with a glass of water, before or after a meal at any time of the day at the time established by the doctor.
The doses of Dapagliflozine 10 mg coated for adults are:
- Type 2 diabetes mellitus (used alone): 1 tablet of 10 mg of dapagliflozine, 1 time per day;
- Type 2 diabetes mellitus (in combination with metformin): 1 10 mg dapagliflozine tablet, 1 once a day, and 1 500 mg metformin tablet 1 once a day. Learn how to take the metformin correctly;
- Heart failure: 1 tablet of 10 mg of dapagliflozine, 1 time per day;
- Chronic kidney disease: 1 tablet of 10 mg of Dapagliflozina, 1 time per day.
Treatment with dapagliflozine should always be guided by the endocrinologist, with blood glucose exams regularly to evaluate the effectiveness of Dapagliflozine in the control of type 2 diabetes.
Also read: Edistride: What is it for, how to take it and side effects
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2. Dapagliflozina + Metformin
Dapagliflozine + metformin (xigdu xr) in the form of prolonged release coated tablet may contain 5 mg or 10 mg + metformin 500 mg or 1000 mg, indicated for adults.
The Dapagliflozine + Metformin tablet should be taken orally, with a glass of water, along with a meal at night.
The recommended initial dose is 1 dapagliflozine tablet 10 mg + metformin 500 mg, once a day. This dose can be modified by the doctor to use up to 2000 mg of metformin per day, keeping the dose of 10 mg of dapagliflozine per day.
Thus, it can be recommended to take 1 tablet of dapagliflozine 10 mg + metformin 1000 mg, once a day, or 2 dapagliflozine tablets 5 mg + metformin 1000 mg 1 once a day.
3. Dapagliflozina + saxagliptina
The Dapagliflozine 10 mg + Saxagliptina 5 mg tablet should be taken orally with a glass of water before or after a meal.
The recommended dose for adults is 1 tablet per day at the time established by the doctor.
Possible side effects
The most common side effects of dapagliflozine are urinary tract infections, vulvovaginal infections, candidiasis, vulvar abscess, bacterial vaginitis, balanoposthitis, balanitis, abscess or penile infection, back pain, willingness to urinate very often or increased amount of urine.
Although rare, dapagliflozine can cause a severe genital infection, called the fasciitis of the Fournier perineum or gangrene. Thus it is recommended to interrupt treatment and go to the emergency room immediately if symptoms such as redness, swelling or sensitivity in the genital region, fever or malaise arise. Understand better what the necrotizing fasciitis is.
In addition, when associated with metformin, nausea, vomiting, diarrhea, belly pain, loss of appetite or changes in the taste may also occur.
When associated with Saxagliptin, side effects such as respiratory tract infection, gastroenteritis, joint pain, headache or increased cholesterol and triglycerides, or acute pancreatitis.
Who should not use
Dapagliflozine should not be used by children, pregnant or breastfeeding women, or people who have type 1 diabetes, chronic renal failure not associated with type 2 diabetes mellitus, diabetic ketoacidosis or allergy to any of the compresses components.
When associated with metformin or saxagliptin, it should not be used either in cases of severe renal or liver failure or metabolic acidosis.
Source: www.tuasaude.com